Refereed Journal Papers
2016
Khosravi R, Best CA, Allen RA, Stowell CET, Onwuka E, Zhuang JJ, Lee YU, Yi T, Bersi MR, Shinoka T, Humphrey JD, Wang Y, Breuer CK. Long-term functional efficacy of a novel electrospun poly(glycerol sebacate)-based arterial graft in mice. Annals of Biomedical Engineering. 44(8):2402-16, 2016. Link
Hassan K. Awada, Mintai P. Hwang, Yadong Wang. Towards comprehensive cardiac repair and regeneration after myocardial infarction: Aspects to consider and proteins to deliver. Biomaterials. 82: 94-112, 2016. Link
2015
Chen C-W, Lee B, Park D, Kim K, Chu H, Kim K, Huard J, and Wang Y. Controlled Dual Delivery of Fibroblast Growth Factor-2 and Interleukin-10 by Heparin-based Coacervate Synergistically Enhances Ischemic Heart Repair. Biomaterials. 72: 138–151, 2015. Link
Johnson NR, Kruger M, Goetsch K, Zilla P, Bezuidenhout D, Wang Y, Davies N. “Coacervate delivery of growth factors combined with a degradable hydrogel preserves heart function after myocardial infarction”. ACS Biomater Sci Eng. 1(9): 753–759, 2015. Link
Sinha M, Stowell C, Gao J, and Wang Y. Synthesis and Biocompatibility of a Biodegradable and Functionalizable Thermo-Sensitive Hydrogel. Regenerative Biomaterials. 177-185, 2015. Link
Johnson NR, Wang Y. Coacervate delivery of HB-EGF accelerates healing of type 2 diabetic wounds. Wound Repair Regen. 66:67-82, 2015. Link
Xie Q, Wang Z, Huang Y1, Bi X, Zhou H, Lin M, Yu Z, Wang Y, Ni N, Sun J, Wu S, You Z, Guo C, Sun H, Wang Y, Gu P, and Fan X. Characterization of human ethmoid sinus mucosa derived mesenchymal stem cells (hESMSCs) and the application of hESMSCs cell sheets in bone regeneration. Biomaterials 66:67-82, 2015. Link
Awada H, Johnson N and Wang Y. Sequential delivery of angiogenic growth factors improves revascularization and heart function after myocardial infarction. J. Control. Release. 207:7-17, 2015. Link
Jeffries E, Allen R, Gao J, Pesce M, and Wang Y. Highly Elastic and Suturable Electrospun Poly(Glycerol Sebacate) Fibrous Scaffolds. Acta Biomater. , 18:30-39, 2015. Link
Johnson NR, Wang Y. Drug delivery systems for wound healing. Curr Pharm Biotech. 16(7): 621-9, 2015. Link
Rauck B, Novosat T, Oudega M, and Wang Y. Biocompatibility of a Coacervate-Based Controlled Release System for Protein Delivery to the Injured Spinal Cord. Acta Biomater. In press. Link
Robertson F, Wang Y, Rosing H. An oligomeric switch that rapidly decreases the peel strength of a pressure sensitive adhesive. Int. J. Adhes. Adhes. 55: 64-8, 2014. Link
Johnson NR, Wang Y. “Controlled Delivery of Sonic Hedgehog with a Heparin-Based Coacervate”. Hedgehog Signaling Protocols, 2nd ed. Methods in Molecular Biology. 1322:1-7. Link
2014
Awada H, Johnson N and Wang Y. Sequential delivery of angiogenic growth factors improves revascularization and heart function after myocardial infarction. J. Control. Release. In Press
Allen RA, Wu W, Yao M, Dutta D, Duan X, Bachman TN, Champion HC, Stolz DB, Robertson AM, Kim K, Isenberg JS, and Wang Y. Nerve regeneration and elastin formation within poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model. Biomaterials. , 35(1):165-73, 2014. Link
Ritfeld GJ, Rauck B, Novosat TL, Park D, Patel P, Roos RAC, Wang Y*, and Oudega M*. The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. Biomaterials. , 35(6): 1924-1931, 2014. Link
Deng Y, Bi X, Zhou H, You Z, Wang Y, Gu P, Fan X. Repair of critical-sized bone defects with anti-miR-31-expressing bone marrow stromal stem cells and poly (glycerol sebacate) scaffolds. European Cells and Materials. , 27, 13-25, 2014. Link
Rauck BM, Friberg TR, Mendez CAM, Park D, Shah V, Bilonick RA, and Wang Y. Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo. Invest. Ophthalmol. Vis. Sci. , 55: 469-476, 2014. Link
Zaky S, Tudares M, Alejandro, Almarza A, Hagandora C, Jensen AD , Gao J, Wang Y, Sfeir C. Poly (glycerol sebacate) elastomer supports osteogenic phenotype for bone engineering applications. Biomed. Mater. , 9, 025003, 2014. Link
Bi X, You Z, Gao J, Fan X, Wang Y. A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix. Acta Biomater. , 10(6):2814-23, 2014. Link
Rauck BM, Novosat TL, Oudega M, Wang Y. Biocompatibility of a coacervate-based controlled release system for protein delivery to the injured spinal cord. Acta Biomaterialia In Press. Link
Jeffries E, Nakamura S, Lee K-W, Clampffer J, Ijima H, and Wang Y. Micropatterning Electrospun Scaffolds to Create Intrinsic Vascular Networks. Macromol. Biosci. 14(11): 1514–1520, 2014. Featured in “Best of Macromolecular Journals-Edition 2015”. Link
Johnson NR, Wang Y. Coacervate delivery systems for proteins and small molecule drugs. Expert Opin Drug Del 11(12):1829-1832. Link
Johnson NR, Ambe T, Wang Y. Lysine-based polycation:heparin coacervate for controllable sustained release. Acta Biomaterialia, 10(1):40-46. Link
Awada HK, Johnson NR, Wang Y. Dual Delivery of Vascular Endothelial Growth Factor and Hepatocyte Growth Factor Coacervate Displays Strong Angiogenic Effects. Macromol Biosci, 14(5):679-686. Link
2013
Rauck BM, Friberg TR, Mendez CAM, Park D, Shah V, Bilonick RA, and Wang Y. Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo. Invest. Ophthalmol. Vis. Sci, In Press. Link
Allen RA, Wu W, Yao M, Dutta D, Duan X, Bachman TN, Champion HC, Stolz DB, Robertson AM, Kim K, Isenberg JS, Wang Y. Nerve regeneration and elastin formation within poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model. Biomaterials, 35:167-73. Link
Yu J, Takanari K, Hong Y, Lee KW, Amoroso N, Wang Y, Wagner W, Kim K. Non-invasive Characterization of Polyurethan-based Tissue Constructs on Rat Abdominal Repair Model Using High Frequency Ultrasound Elasticity Imaging. Biomaterials, 34(11):2701-2709. Link
Dutta D, Lee KW, Allen RA, Wang Y, Brigham JC, Kim K. Non-invasive Assessment of Elastic Modulus in Arterial Constructs During Cell Culture using Ultrasound Elasticity Imaging. Ultrasound in Med & Biol, 39(11):2103-2115. Link
Lee KW, Johnson NR, Gao J, Wang Y. Human Progenitor Cell Recruitment via SDF-1 alpha Coacervate-laden PGS Vascular Grafts.Biomaterials, 34(38):9877-9885. Link
Zaky SH, Lee KW, Gao J, Jensen A, Wang Y, Almarza AJ, Sfeir C. Poly(glycerol sebacate) Elastomer, a Novel Material for Mechanically Loaded Bone Regeneration. Tissue Eng Part A. , In press. Link
Jeffries EM, Wang Y. Incorporation of parallel electrospun fibers for improved topographical guidance in 3D nerve guides. Biofabrication, 5(3). Link
Johnson NR, Li H, Usas A, Lu A, Wang Y, Huard J. Sustained Release of BMP2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells. Stem Cells Transl Med, 2(9):667-77. Link
Johnson NR and Wang Y. Controlled delivery of Sonic hedgehog morphogen and its potential for cardiac repair. PLoS One, 8(5): e63075. Link
Park D, Shah V, Rauck B, Friberg TR, and Wang Y. An anti-angiogenic reverse thermal gel as a drug delivery system for age-related wet macular degeneration. Macromol. Biosci, In Press. Link
Chu H, Chen C-W, Huard J, and Wang Y. The effect of a heparin-based coacervate of fibroblast growth factor-2 on scarring in the infarcted myocardium. Biomaterials, 34(6):1747-56. Link
Johnson N and Wang Y. Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing. J. Control. Release, 166(2):124-9. Link
Park D, Larson AM, Klibanov AM, Wang Y. Antiviral and antibacterial polyurethanes of various modalities. App. Biochem. Biotechnol., 169(4): 1134-1146. Link
Hagandora K, Gao J, Wang Y, Almarza AJ. Poly (glycerol sebacate): a novel scaffold material for temporomandibular joint disc engineering. Tissue Eng., 19(5-6): 729-737. Link
2012
Bae H, Chu H, Edalat F, Cha JM, Sant S, Kashyap A, Ahari AF, Kwon CH, Nichol JW, Manoucheri S, Zamanian B, Wang Y, and Khademhosseini A. Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications. J Tissue Eng Regen Med. , 6: 1-14. Link
Chu H, and Wang Y. Therapeutic Angiogenesis: Controlled Delivery of Angiogenic Factors. Therapeutic Delivery, 3: 693-714. Link
You Z, Wang Y. A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials. Advanced Functional Materials, 22: 2812-20. Link
Wu W, Allen R, and Wang Y. Fast Degrading Elastomer Enables Rapid Remodeling of a Cell-Free Synthetic Graft into a Neo-Artery. Nature Medicine, 18: 1148-1153. Link
Jeffries EM and Wang Y. Biomimetic Micropatterned Multi-channel Nerve Guides by Templated Electrospinning. Biotechnology and Bioengineering, 109: 1571-82. Link
You Z, Bi X, and Wang Y. Fine Control of Polyester Properties via Epoxide-opening Polymerization Using Monomers Carrying Diverse Functional Groups. Macromolecular Bioscience, 12: 822-9. Link
Chu H, Gao J, and Wang Y. Design, synthesis, and biocompatibility of an arginine-based polyester. Biotechnology Progress., 28: 257-264. Link
You Z, Bi X, Fan X, and Wang Y. A functional polymer designed for bone tissue engineering. Acta Biomaterialia., 8: 502-510. Link
You Z, Bi X, Jeffries EM, and Wang Y. A biocompatible, metal-free catalyst and its application in microwave-assisted synthesis of functional polyesters. Polymer Chemistry, 3:384-389. Link
2011
Allen, R and Wang Y. Rapid Self-Assembly of Tubular Arterial Media Layer from Smooth Muscle Cells in Transient Fibrin Gel.J Tissue Sci Eng. 2:105e. Link
Chu H, Gao J, Chena C, Huard J, and Wang Y. Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis. PNAS. Link
Zern BJ, Chu H, Osunkoya AO, Gao J, and Wang Y. A Biocompatible Arginine-based Polycation. Adv. Func. Mater., 21: 434-440. Link
Chu H, Johnson NR, Mason NS, and Wang Y. A [polycation:heparin] complex releases growth factors with enhanced bioactivity. J. Control. Release, 150, 157-163. Link
Park D, Wu W, and Wang Y. A functionalizable reverse thermal gel based on a polyurethane / PEG block copolymer. Biomaterials, 32:777-786. Link
Crapo P and Wang Y. Hydrostatic Pressure Independently Increases Elastin and Collagen Co-expression in Small-diameter Engineered Arterial Constructs. J. Biomed. Mat. Res., 96(4):673-81. Link
Lee K-W, Stolz DB, and Wang Y. Substantial Expression of Mature Elastin in Arterial Constructs. Proc. Natl. Acad. Sci. U.S.A., 108:2705-10. Link
Wu W, Allen R, Gao J, and Wang Y. Artificial Niche Combining Elastomeric Substrate and Platelet Guided Vascular tissue formation of Bone Marrow Mononuclear Cells. Tissue Eng Link
Gumera C, Rauck B, and Wang Y. Materials for Central Nervous System Regeneration: Bioactive Cues. J. Mater. Chem., 21, 7033 – 7051 Link
Lee K-W and Wang Y: Elastomeric PGS Scaffolds in Arterial Tissue Engineering. http://www.jove.com/details.stp?id=2691 doi: 10.3791/2691. J. Vis. Exp. 50 Link
Wilson ME, Kota N, Kim YT, Wang Y, Stolz DB, LeDuc P, and Ozdoganlar BO. Fabrication of Circular Microfluidic Channels by Combining Mechanical Micromilling and Soft Lithography. Lab Chip. 11, 1550-1555 Link
2010
Crapo PM and Wang Y. Small Intestinal Submucosa Gel as a Potential Scaffolding Material for Cardiac Tissue Engineering. Acta Biomater., 2091-2096 Link
Crapo PM and Wang Y. Physiologic Compliance In Engineered Small-Diameter Arterial Constructs Based On An Elastomeric Substrate. Biomaterials, 31: 1626-1635 Link
You Z, Cao H, Gao J, Shin, PH, Day BW, and Wang Y. A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties. Biomaterials, 31: 3129-3138 Link
Zern BJ, Chu H, and Wang Y. Control growth factor release using a self-assembled [polycation:heparin] complex. PLoS ONE, 5, e11017. doi:10.1371 Link
Marsano A, Maidhof R, Wan LQ, Wang Y, Gao J, Tandon N, and Vunjak-Novakovic G. Scaffold stiffness affects the contractile function of three dimensional engineered cardiac constructs, Biotechnol. Prog., 26: 1382-1390 Link
2009
Secasanu V, Giardina C, and Wang Y. A novel electrospinning target for improved yield of uniaxially aligned fibers. Biotechnol. Prog. 25: 1169-1175 Link
Lee EJ, Vunjak-Novakovic G, Wang Y, and Niklason LE. A biocompatible endothelial cell delivery system for in vitro tissue engineering. Cell Transplant. 18: 731-743 Link
2008
Gao J, Crapo PM, Nerem R, and Wang Y. Co-Expression of Elastin and Collagen Leads to Highly Compliant Engineered Blood Vessels. J. Biomed. Mat. Res. 85A: 1120-1128 Link
Crapo PM, Gao J, and Wang Y. Seamless Tubular Poly(glycerol sebacate) Scaffolds: High-yield Fabrication and Potential Applications. J. Biomed. Mat. Res. 86: 354-363 Link
Radisic M, Park H, Salazar-Lazaro JE, Wang Y, Langer R, Freed LE, and Vunjak-Novakovic G. Pretreatment of Synthetic Elastomer Scaffolds by Cardiac Fibroblasts Improves Engineered Heart Tissue. J. Biomed. Mat. Res. 86: 713-724 Link
Radisic M, Marsano A, Maidhof R, Wang Y, and Vunjak-Novakovic G. Cardiac tissue engineering using perfusion bioreactor systems. Nat. Protoc. 3: 719-738 Link
2007
Gumera C and Wang Y. Modulating neuronal responses by controlled integration of acetylcholine-like functionalities in biomimetic polymers. Adv. Mater. 19: 4404-4409 Link
Gao J, Ensley A, Nerem R, and Wang Y. Poly (glycerol sebacate) Supports the Proliferation and Phenotypic Protein Expression of Primary Baboon Vascular Cells. J. Biomed. Mat. Res. 83: 1070-1075 Link
Kim YM, Gao J, Zern B, and Wang Y. Biofunctional materials for Nerve Regeneration. Mater. Sci. Forum, 539: 547-550 Link
Sales VL, Engelmayr GC, Gottlieb D, Johnson JA, Gao J, Wang Y, Sacks MS, and Mayer JE. Protein Precoating of Elastomeric Tissue-Engineering Scaffolds: Extracellular Matrix Formation and Phenotypic Changes of Circulating Endothelial Progenitor Cells. Circ. Res., 99: e35 Link
2006
Gao J, Crapo PM, and Wang Y. Macroporous Elastomeric Scaffolds with Extensive Micropores for Soft Tissue Engineering. Tissue Eng., 12: 917-925 Link
Gao J, Kim YM, Coe H, Zern B, Sheppard B, and Wang Y. A Neuro-inductive Biodegradable Material Based on Dopamine. Proc. Natl. Acad. Sci. U.S.A., 103: 16681-16686 Link
Radisic M, Park H, Chen F, Wang Y, Dennis R, Langer R, Freed LE, and Vunjak-Novakovic G. Biomimetic Approach to Cardiac Tissue Engineering: Oxygen Carriers and Channeled Scaffolds. Tissue Eng., 12: 1-15 Link
Bettinger CJ, Weinberg E, Wang Y, Borenstein J, and Langer R. Three-dimensional Microfluidic Tissue Engineering Scaffolds Using a Flexible Biodegradable Polymer. Adv. Mater. 18: 165-169 Link
2005
Fidkowski C, Kaazempur-Mofrad MR, Borenstein J, Vacanti JP, Langer R, and Wang Y. Endothelialized Microvasculature Based on a Biodegradable Elastomer. Tissue Eng., 11: 302-309 Link
Haaga J, Exner A, Wang Y, Stowe N, and Tarcha PJ. Combined Tumor Therapy by Using Radiofrequency Ablation and 5-FU-Laden Polymer Implants: Evaluation in Rats and Rabbits. Radiology, 911-918 Link
Sundback CA, Shyu JY, Wang Y, Faquin WC, Langer R, Vacanti JP, and Hadlock TA. Biocompatibility Analysis of Poly(glycerol sebacate) as a Nerve Guide Material. Biomaterials, 26: 5454-5464 Link
1996-2004
Ijima H, Wang Y, and Langer R. Spheroid Formation and Expression of Liver Specific Functions of Primary Rat Hepatocytes Co-cultured with Bone Marrow Cells. Biochem. Eng. J., 20: 223-228 Link
Wang Y, Kim YM, and Langer R. In vivo Degradation characteristics of Poly(glycerol sebacate). J. Biomed. Mat. Res. 66A: 192-197 Link
Wang Y, Ameer GA, Sheppard BJ, and Langer R. A Tough Biodegradable Elastomer. Nat. Biotechnol., 20: 602-606 Link
Wang Y, DuBois JL. Hedman B, Hodgson KO, and Stack TDP Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity. Science, 279: 537-540 Link
Wang Y and Stack, TDP. Galactose Oxidase Model Complexes: Catalytic Reactivities. J. Am. Chem. Soc., 118: 13097-13098 Link
